rs2682818/MiR-618 is a novel marker associated with increased risk of breast cancer in the Iranian population

rs2682818/MiR-618 is a novel marker associated with increased risk of breast cancer in the Iranian population

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The presence of single nucleotide variations in the coding region of micro-RNA (miRNA)-encoding genes plays a significant role in the expression and function of these molecules in oncogenesis and cancer.The association of rs2682818 in miR-618 with increased risk of breast cancer was investigated in the Iranian population.rs2682818/miR-618 was genotyped using amplification-refractory mutation system PCR (ARMS-PCR) cardboard sweet stand in 200 healthy individuals and patients with breast cancer.

The data revealed the presence of Hardy-Weinberg equilibrium (HWE) for this marker.The frequency of alleles C and A was 70% and 30%, respectively, in healthy individuals; the frequency of alleles C and A was 44% and 56%, respectively, in patients with breast cancer.Analysis of odd ratios showed that the rs2682818/miR-618 polymorphism is life extension blueberry extract associated with increased probability of breast cancer and is statistically significant (OR=2.

97, P=0.0003).The data suggest that rs2682818/miR-618 could be considered a novel marker of increased risk of breast cancer.